Article
Association of mutations in grlA and gyrA topoisomerase genes with resistance to ciprofloxacin in epidemic and sporadic isolates of methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Sept 1997
Deplano A, Zekhnini A, Allali N, Couturier M, Struelens M J
Abstract excerpt
The types of topoisomerase alterations in genomically diverse epidemic and sporadic strains of methicillin- and fluoroquinolone-resistant Staphylococcus aureus isolated from European hospitals between 1984 and 1994 were characterized. Convergent dual mutations in gyrA (codon 83, 84, or 88) and gr...
Topics
- Anti-Infective Agents
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Disease Outbreaks
- Genes, Bacterial
- Methicillin Resistance
- Microbial Sensitivity Tests
- Mutation
- Staphylococcus aureus