Article
Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays.
International journal of cancer - 15 Nov 2009
Chen Meng, Ye Yuanqing, Yang Hushan, Tamboli Pheroze, Matin Surena, Tannir Nizar M, Wood Christopher G, Gu Jian, Wu Xifeng
Abstract excerpt
The identification of genetic aberrations may help understand the mechanisms of tumorigenesis and has important implications in diagnosis, prognosis and treatment. We applied Illumina's 317K high-density single nucleotide polymorphism (SNP) arrays to profile chromosomal aberrations in clear cell renal cell carcinoma (ccRCC) from 80 patients and analyzed the association of LOH/amplification events with...
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