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Article

Using hidden Markov models and observed evolution to annotate viral genomes.

Bioinformatics (Oxford, England) - 1 Jun 2006

McCauley Stephen, Hein Jotun

Abstract excerpt

MOTIVATION: ssRNA (single stranded) viral genomes are generally constrained in length and utilize overlapping reading frames to maximally exploit the coding potential within the genome length restrictions. This overlapping coding phenomenon leads to complex evolutionary constraints operating on the genome. In regions which code for more than one protein, silent mutations in one reading frame generally have a...

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PMID: 16613911
DOI: 10.1093/bioinformatics/btl092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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