Article
A model-based information sharing protocol for profile Hidden Markov Models used for HIV-1 recombination detection.
BMC bioinformatics - 19 Jun 2014
Bulla Ingo, Schultz Anne-Kathrin, Chesneau Christophe, Mark Tanya, Serea Florin
Abstract excerpt
BACKGROUND: In many applications, a family of nucleotide or protein sequences classified into several subfamilies has to be modeled. Profile Hidden Markov Models (pHMMs) are widely used for this task, modeling each subfamily separately by one pHMM. However, a major drawback of this approach is the difficulty of dealing with subfamilies composed of very few sequences. One of the most crucial bioinformatical tasks...
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