Article
Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila.
Molecular and cellular biology - 1 May 2006
Rasheva Vanya I, Knight David, Bozko Przemyslaw, Marsh Katherine, Frolov Maxim V
Abstract excerpt
E2F and retinoblastoma tumor suppressor protein pRB are important regulators of cell proliferation; however, the regulation of these proteins in vivo is not well understood. In Drosophila there are two E2F genes, an activator, de2f1, and a repressor, de2f2. The loss of de2f1 gives rise to the G(1)/S block accompanied by the repression of E2F-dependent transcription. These defects can be suppressed by mutation of...
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