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Article

Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor.

Molecular and cellular biology - 1 Nov 1995

Peng X, Mount S M

Abstract excerpt

SR proteins are essential for pre-mRNA splicing in vitro, act early in the splicing pathway, and can influence alternative splice site choice. Here we describe the isolation of both dominant and loss-of-function alleles of B52, the gene for a Drosophila SR protein. The allele B52ED was identified as a dominant second-site enhancer of white-apricot (wa), a retrotransposon insertion in the second intron of the eye...

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Identifiers

PMID: 7565780
DOI: 10.1128/MCB.15.11.6273
PMCID: PMC230879

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