Article
Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor.
Molecular and cellular biology - 1 Nov 1995
Peng X, Mount S M
Abstract excerpt
SR proteins are essential for pre-mRNA splicing in vitro, act early in the splicing pathway, and can influence alternative splice site choice. Here we describe the isolation of both dominant and loss-of-function alleles of B52, the gene for a Drosophila SR protein. The allele B52ED was identified...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Drosophila Proteins
- Drosophila melanogaster
- Frameshift Mutation
- Genes, Dominant
- Genes, Insect
- Molecular Sequence Data
- Nuclear Proteins
- Phosphoproteins
- Point Mutation
- Protein Structure, Tertiary
- Proteins
- RNA Splicing
- RNA Splicing Factors