T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.

doi:10.1128/jvi.76.23.12360-12364.2002

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Article

T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.

Journal of virology - 1 Dec 2002

Münch Jan, Janardhan Ajit, Stolte Nicole, Stahl-Hennig Christiane, Ten Haaft Peter, Heeney Jonathan L, Swigut Tomek, Kirchhoff Frank, Skowronski Jacek

Abstract excerpt

We investigated the function of severely truncated simian immunodeficiency virus (SIV) Nef proteins (tNef) in vitro and in vivo. These variants emerged in rhesus monkeys infected with SIVmac239 containing a 152-bp deletion in the nef-unique region and have been suggested to enhance SIV virulence (E. T. Sawai, M. S. Hamza, M. Ye, K. E. Shaw, and P. A. Luciw, J. Virol. 74:2038-2045, 2000). We found that the tNef...

Topics

Amino Acid Sequence
Animals
Down-Regulation
Genes, nef
Genetic Variation
Humans
Jurkat Cells
Macaca mulatta
Molecular Sequence Data
Receptor-CD3 Complex, Antigen, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Viral Regulatory and Accessory Proteins

Virulence

Virus Replication

Source

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Identifiers

PMID: 12414978
DOI: 10.1128/jvi.76.23.12360-12364.2002
PMCID: PMC136863

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