Article
Conservation of Nef function across highly diverse lineages of SIVsmm.
Retrovirology - 9 Apr 2009
Schmökel Jan, Li Hui, Bailes Elizabeth, Schindler Michael, Silvestri Guido, Hahn Beatrice H, Apetrei Cristian, Kirchhoff Frank
Abstract excerpt
BACKGROUND: SIVsmm is a simian immunodeficiency virus that persists efficiently without causing disease in naturally infected sooty mangabeys (SMs) but induces AIDS upon cross-species transmission to humans and macaques. Current phylogenetic data indicate that SIVsmm strains comprise a highly diverse group of viruses that can be subdivided into different lineages. Since only certain SIVsmm strains have...
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