Article
Implication of the C-terminal domain of nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques.
Virology - 20 Jan 2000
Lafont B A, Rivière Y, Gloeckler L, Beyer C, Hurtrel B, Paule Kieny M, Kirn A, Aubertin A M
Abstract excerpt
We have analyzed the nef gene sequences amplified from 12 macaques presenting various patterns of infection with SIVmacBK28-41, a clone derived from attenuated SIVmacBK28. We have observed seven mutation hot spots at positions 56, 75, 432, 588, 680, 699, and 779. The major alteration was a thymidine insertion at position 699, leading to a frameshift in the SIVmacBK28-41 nef gene and changing the last 15 amino...
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