Alternative lengthening of telomeres—An enhanced chromosomal instability in aggressive non‐MYCN amplified and telomere elongated neuroblastomas

Abstract excerpt

Telomere length alterations are known to cause genomic instability and influence clinical course in several tumor types, but have been little investigated in neuroblastoma (NB), one of the most common childhood tumors. In the present study, telomere-dependent chromosomal instability and telomere length were determined in six NB cell lines and fifty tumor biopsies. The alternative lengthening of telomeres (ALT)...

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