Article
Effects of protein kinase A and calcium/phospholipid-dependent kinase modulators in the process of HL-60 cell differentiation: their opposite effects between HL-60 cell and K-562 cell differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1991
Okuda T, Sawada H, Kato Y, Yumoto Y, Ogawa K, Tashima M, Okuma M
Abstract excerpt
We have previously shown that HL-60 cells treated with 1 alpha, 25-(OH)2D3 in magnesium-deficient medium are committed to differentiate but do not express differentiation-related phenotypes. In the present study, we demonstrated that Mg2+ deprivation blocked the process of differentiation before the induction of lysozyme mRNA and that the process of HL-60 cell differentiation could be divided into two steps,...
Topics
- Alkaloids
- Calcium
- Cell Differentiation
- Cell Line
- Cholecalciferol
- Diglycerides
- Enzyme Activation
- Gene Expression Regulation
- Isoquinolines
- Leukemia, Promyelocytic, Acute