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Article

A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts.

Archives of gerontology and geriatrics - 1 Jan 2000

Matuoka Koozi, Chen Kuang Yu, Takenawa Tadaomi

Abstract excerpt

In order to detect the role that phosphatidylinositol 3-kinase (PI3K) plays in the aging of human diploid fibroblasts, we analyzed cellular inositol phospholipids and expression of PI3Ks. In aged cells a decrease in phosphatidylinositol 3,4-bisphosphate (PI3,4P(2)) was notable, while phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) decreased slightly. On the other...

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PMID: 12849077
DOI: 10.1016/s0167-4943(02)00151-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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