Article
Up-regulation of Ca2+ influx mediated by store-operated channels in HL60 cells induced to differentiate by 1 alpha,25-dihydroxyvitamin D3.
Journal of cellular physiology - 1 Sept 1997
Gardner J P, Balasubramanyam M, Studzinski G P
Abstract excerpt
The physiologically active form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 (1,25D3), induces promyelocytic HL60 cells to differentiate towards monocyte-like cells. During this differentiation increased cytosolic calcium (Cai2+) and expression of surface receptors for chemotactic factors "prime"...
Topics
- Adenosine Triphosphate
- Calcitriol
- Calcium
- Calcium Channels
- Cell Differentiation
- Ethanol
- HL-60 Cells
- Humans
- Lipopolysaccharide Receptors
- Macrophage-1 Antigen
- Manganese
- Monocytes
- N-Formylmethionine Leucyl-Phenylalanine
- Phenotype
- Signal Transduction
- Thapsigargin
- Up-Regulation
