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Article

Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton.

Molecular biology of the cell - 1 Mar 2005

Komati Hiba, Naro Fabio, Mebarek Saida, De Arcangelis Vania, Adamo Sergio, Lagarde Michel, Prigent Annie-France, Némoz Georges

Abstract excerpt

We investigated the role of phospholipase D (PLD) and its product phosphatidic acid (PA) in myogenic differentiation of cultured L6 rat skeletal myoblasts. Arginine-vasopressin (AVP), a differentiation inducer, rapidly activated PLD in a Rho-dependent way, as shown by almost total suppression of activation by C3 exotoxin pretreatment. Addition of 1-butanol, which selectively inhibits PA production by PLD,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15616193
DOI: 10.1091/mbc.e04-06-0459
PMCID: PMC551488

Genes

AVP
PLD1
PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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