Article
Yeast cells lacking the mitochondrial gene encoding the ATP synthase subunit 6 exhibit a selective loss of complex IV and unusual mitochondrial morphology.
The Journal of biological chemistry - 13 Apr 2007
Rak Malgorzata, Tetaud Emmanuel, Godard François, Sagot Isabelle, Salin Bénédicte, Duvezin-Caubet Stéphane, Slonimski Piotr P, Rytka Joanna, di Rago Jean-Paul
Abstract excerpt
Atp6p is an essential subunit of the ATP synthase proton translocating domain, which is encoded by the mitochondrial DNA (mtDNA) in yeast. We have replaced the coding sequence of Atp6p gene with the non-respiratory genetic marker ARG8m. Due to the presence of ARG8m, accumulation of rho-/rho0 petites issued from large deletions in mtDNA could be restricted to 20-30% by growing the atp6 mutant in media lacking...
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