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Article

A genetic screen targeted on the FO component of mitochondrial ATP synthase in Saccharomyces cerevisiae.

The Journal of biological chemistry - 20 May 2011

Godard François, Tetaud Emmanuel, Duvezin-Caubet Stéphane, di Rago Jean-Paul

Abstract excerpt

In yeast, the two main F(O) proton-translocating subunits of the ATP synthase (subunits 6/a and 9/c) are encoded by mitochondrial DNA (mtDNA). Unfortunately, mutations that inactivate the F(O) typically result in loss of mtDNA under the form of ρ(-)/ρ(0) cells. Thus, we have designed a novel genetic strategy to circumvent this problem. It exploits previous findings that a null mutation in the nuclear ATP16 gene...

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Identifiers

PMID: 21454598
DOI: 10.1074/jbc.M110.214825
PMCID: PMC3093890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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