Article
A lifetime of retinal light exposure does not appear to increase mitochondrial mutations.
Gene - 15 Dec 1991
Bodenteich A, Mitchell L G, Merril C R
Abstract excerpt
Recently, there have been a number of reports of an accumulation of mutations in the mitochondrial (mt) genome with age. Such mutations may be due in part to the mt oxidative metabolic pathways which provide most of the cell's energy, but also generate free radicals. In addition, the mt genome in some tissues, such as the retina, may also accumulate mutations from the effects of ultraviolet light. To obtain...
Topics
- Aged
- Aging
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA Repair
- DNA, Mitochondrial
- Electron Transport Complex IV
- Female
- Humans
- Mitochondria
- Molecular Sequence Data