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Article

The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye.

Mutagenesis - 31 May 2021

Gary Anne-Sophie, Dorr Marie M, Rochette Patrick J

Abstract excerpt

The mitochondrial mutation T414G (mtDNAT414G) has been shown to accumulate in aged and sun-exposed skin. The human eye is also exposed to solar harmful rays. More precisely, the anterior structures of the eye (cornea, iris) filter UV rays and the posterior portion of the eye (retina) is exposed to visible light. These rays can catalyse mutations in mitochondrial DNA such as the mtDNAT414G, but the latter has...

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Identifiers

PMID: 33453104
DOI: 10.1093/mutage/geab003
PMCID: PMC8166345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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