Article
CC to TT mutation in the mitochondrial DNA of normal skin: relationship to ultraviolet light exposure.
Mutation research - 22 Jun 2000
Kawasaki K, Suzuki1 T, Ueda M, Ichihashi M, Reguer G, Yamasaki H
Abstract excerpt
We have previously reported that ultraviolet (UV)-specific (CC to TT) mutations in p53 gene can be detected in normal skin. This, however, cannot be used as a cumulative marker of UV exposure, since cells with the p53 mutation acquire a clonal growth advantage. Moreover, a large skin biopsy is necessary for each assay. In order to circumvent these problems, we have measured mitochondrial (Mt) DNA mutations; there...
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