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Article

Computational protein design suggests that human PCNA-partner interactions are not optimized for affinity.

Proteins - 1 Feb 2013

Fridman Yearit, Gur Eyal, Fleishman Sarel J, Aharoni Amir

Abstract excerpt

Increasing the affinity of binding proteins is invaluable for basic and applied biological research. Currently, directed protein evolution experiments are the main approach for generating such proteins through the construction and screening of large mutant libraries. Proliferating cell nuclear an...

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Source

Identifiers

PMID: 23011891
DOI: 10.1002/prot.24190

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23011891-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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