Article

Orchestrated Restructuring Events During Secretory Granule Maturation Mediate Intragranular Cargo Segregation

2021-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Regulated secretion is an essential process where proteins are packaged into membranous secretory vesicles. However, the details of cargo packaging and secretory granule maturation are largely unknown. Here, we demonstrate that multiple distinct proteins undergo intragranular restructuring during secretory granule maturation in vivo, resulting in spatial segregation of distinct protein component...

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Literature Corpus work: 2644f230-75ca-5feb-baaf-1f962aeb5b3b
DOI: 10.1101/2021.08.16.456250

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