Article
Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.
The EMBO journal - 19 Apr 2006
Tréand Céline, du Chéné Isaure, Brès Vanessa, Kiernan Rosemary, Benarous Richard, Benkirane Monsef, Emiliani Stéphane
Abstract excerpt
Activation of the human immunodeficiency virus type-1 (HIV-1) promoter in infected cells requires the sequential recruitment of several cellular factors to facilitate the formation of a processive elongation complex. The nucleosomal reorganization of the HIV-1 long terminal repeat (LTR) observed upon Tat stimulation suggests that chromatin-remodeling complexes could play a role during this process. Here, we...
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