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Article

MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.

PloS one - 1 Jan 2015

Pereira Lloyd A, Hugo Honor J, Malaterre Jordane, Huiling Xu, Sonza Secondo, Cures Alina, Purcell Damian F J, Ramsland Paul A, Gerondakis Steven, Gonda Thomas J, Ramsay Robert G

Abstract excerpt

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem loop (SLR) followed by a polyU tract. We report that NFκBp50 can bind the SLR polyU RNA and promote MYB transcriptional elongation together with NFκBp65. We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFκBp50, mutation of which abrogated the...

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Share to DNA-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25853889
DOI: 10.1371/journal.pone.0122919
PMCID: PMC4390348

Genes

MYB
RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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