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Article

Genetic Modifiers of Tauopathy in Drosophila

1 Nov 2003

Abstract excerpt

In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in the tau gene cause familial frontotemporal dementia. To investigate the molecular mechanisms responsible for Tau-induced neurodegeneration, we conducted a genetic modifier screen in a Drosophila model of tauopathy. Kinases and phosphatases...

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PMID: 14668378
DOI: 10.1093/genetics/165.3.1233

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