Article
Combined genome and proteome approach to identify new susceptibility genes.
American journal of medical genetics - 30 May 2002
Pociot Flemming, Karlsen Allan E
Abstract excerpt
Type 1 diabetes mellitus (T1DM) is a multifactorial disorder characterized by a specific destruction of the insulin-producing beta cells in the islets of Langerhans. Cells from the immune system infiltrate the islet during the pathogenesis, releasing a mixture of cytokines demonstrated to be specifically toxic to the beta cells within the islets. The goal is to understand the molecular mechanisms responsible for...
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