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Article

Polymorphisms in glutathione-related genes affect methylmercury retention.

Archives of environmental health - 1 Nov 2004

Custodio Hipolito M, Broberg Karin, Wennberg Maria, Jansson Jan-Håkan, Vessby Bengt, Hallmans Göran, Stegmayr Birgitta, Skerfving Staffan

Abstract excerpt

Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC,...

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Source

Identifiers

PMID: 16599007
DOI: 10.1080/00039890409603438

Genes

GCLC
GSTP1
GCLM
GSTA1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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