Article
Glutathione transferase T1 phenotype affects the toxicokinetics of inhaled methyl chloride in human volunteers.
Pharmacogenetics - 1 Oct 2000
Löf A, Johanson G, Rannug A, Warholm M
Abstract excerpt
The aim of the present study was to investigate how the genetic polymorphism in glutathione transferase T1 (GSTT1) affects the metabolism and disposition of methyl chloride in humans in vivo. The 24 volunteers (13 males and 11 females) who participated in the study were recruited from a group of 208 individuals previously phenotyped for GSTT1 by measuring the glutathione transferase activity with methyl chloride...
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