Article
Genetic polymorphisms in glutathione (GSH-) related genes affect the plasmatic Hg/whole blood Hg partitioning and the distribution between inorganic and methylmercury levels in plasma collected from a fish-eating population.
BioMed research international - 1 Jan 2014
de Oliveira Andréia Ávila Soares, de Souza Marilesia Ferreira, Lengert André van Helvoort, de Oliveira Marcelo Tempesta, Camargo Rossana Batista de Oliveira Godoy, Braga Gilberto Úbida Leite, Cólus Ilce Mara de Syllos, Barbosa Fernando, Barcelos Gustavo Rafael Mazzaron
Abstract excerpt
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by...
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