Article
Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)
20 Apr 2011
Abstract excerpt
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. Genetic and epigenetic alterations have been identified frequently in lung cancer, such as promoter methylation, gene mutations and genomic amplification. However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood. METHODS: We determined the promoter...