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Article

Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling.

Annals of surgical oncology - 1 Mar 2010

Suzuki Makoto, Wada Hironobu, Yoshino Mitsuru, Tian Lei, Shigematsu Hisayuki, Suzuki Hidemi, Alaa Mahmoud, Tamura Hajime, Fujiwara Taiki, Nagato Kaoru, Motohashi Shinichiro, Moriya Yasumitsu, Hoshino Hidehisa, Yoshida Shigetoshi, Shibuya Kiyoshi, Hiroshima Kenzo, Nakatani Yukio, Yoshino Ichiro

Abstract excerpt

BACKGROUND: The aim of this study was to evaluate the molecular influence of chronic obstructive pulmonary diseases (COPD) on the pathogenesis of non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: The methylation profiles of 12 genes, and the epidermal growth factor receptor (EGFR) and KRAS mutations were determined for samples from 229 NSCLC patients. In addition, protein expression of EGFR and HER2 in...

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Source

Identifiers

PMID: 19841986
DOI: 10.1245/s10434-009-0739-3

Genes

EGFR
KRAS
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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