Article
CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.
International journal of cancer - 1 Mar 2011
Koga Takaomi, Takeshita Masafumi, Yano Tokujiro, Maehara Yoshihiko, Sueishi Katsuo
Abstract excerpt
Aberrant promoter methylation of the checkpoint gene with forkhead-associated domain and ring finger (CHFR) gene is frequently detected in human cancer. We previously demonstrated that diminished CHFR expression was significantly correlated with both poor prognosis and heavy smoking in nonsmall cell lung cancer (NSCLC). Conversely, epidermal growth receptor (EGFR) mutation is detected in NSCLC among those who...
Topics
- Aged
- Carcinoma, Non-Small-Cell Lung
- Cell Cycle Proteins
- DNA Methylation
- ErbB Receptors
- Female
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Poly-ADP-Ribose Binding Proteins
- Treatment Outcome
- Ubiquitin-Protein Ligases