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Article

Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.

Cancer research - 1 Feb 2006

Toyooka Shinichi, Tokumo Masaki, Shigematsu Hisayuki, Matsuo Keitaro, Asano Hiroaki, Tomii Kunitoshi, Ichihara Shuji, Suzuki Makoto, Aoe Motoi, Date Hiroshi, Gazdar Adi F, Shimizu Nobuyoshi

Abstract excerpt

Genetic and epigenetic alterations are considered to play important roles in lung cancer. Recent studies showed that EGFR and K-RAS mutations exhibited a mutually exclusive pattern in adenocarcinoma of the lung, suggesting the presence of two independent oncogenic pathways. However, it is unknown how epigenetic alterations were involved in lung carcinogenesis mediated by EGFR or K-RAS mutation. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genes, erbB-1

Share to Genes, ras

Share to Genes, Tumor Suppressor

Share to Lung Neoplasms

Share to Smoking

Source

Identifiers

PMID: 16452191
DOI: 10.1158/0008-5472.CAN-05-2625

Genes

EGFR
CDH13
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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