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Article

An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer.

Breast cancer research and treatment - 1 Oct 2006

Bu Dawei, Tomlinson Gail, Lewis Cheryl M, Zhang Cindy, Kildebeck Eric, Euhus David M

Abstract excerpt

XRCC1 coordinates the activities of DNA polymerase-beta and DNA ligase for base excision repair of oxidative DNA damage. In addition, there is some evidence that XRCC1 is a negative regulator of apoptosis. Single nucleotide polymorphisms in XRCC1 have been inconsistently associated with breast cancer risk. We evaluated XRCC1 gene expression in breast cancer cell lines and carcinogen-induced apoptosis in benign...

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Source

Identifiers

PMID: 16596326
DOI: 10.1007/s10549-006-9210-3

Genes

XRCC1
PLAG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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