Female predominance and X chromosome defects in autoimmune diseases.

Abstract excerpt

It is known that autoimmune diseases cumulatively affect 5-10% of the general population. Although knowledge of pathogenesis has become more refined, laboratory diagnosis more accurate, and therapy more effective, the reasons for the female preponderance of these conditions remain unclear. The most intriguing theory to explain the female preponderance is currently related to sex chromosomes, as women with...

Topics

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• Autoimmune Diseases
• Chimerism
• Chromosomes, Human, X
• Fetal Development
• Gene Dosage