Article
Mutations in mutT genes of Mycobacterium tuberculosis isolates of Beijing genotype.
Journal of medical microbiology - 1 May 2006
Lari Nicoletta, Rindi Laura, Bonanni Daniela, Tortoli Enrico, Garzelli Carlo
Abstract excerpt
Missense alterations in genes mutT4 and mutT2, which encode DNA repair enzymes, were sequenced from 30 clinical isolates of Mycobacterium tuberculosis of Beijing genotype, mostly from patients with primary tuberculosis, to evaluate their contribution to anti-mycobacterial drug resistance. The mutation Arg to Gly at codon position 48 (CGG to GGG) of mutT4 was found in 21 isolates; of these, 16 isolates also...
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