Article
The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.
Virology - 10 May 2000
Parker L M, Harris S, Gossen M, Botchan M R
Abstract excerpt
Bovine papillomavirus type 1 (BPV-1) encodes two regulatory proteins, E1 and E2, that are essential for viral replication and transcription. E1, an ATP-dependent helicase, binds to the viral ori and is essential for viral replication, while the viral transcriptional activator, E2, plays cis-dominant roles in both viral replication and transcription. At low reporter concentrations, E1 stimulates E2 enhancer...
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