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Article

The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins.

Molecular and cellular biology - 1 Nov 2003

Zobel Thomas, Iftner Thomas, Stubenrauch Frank

Abstract excerpt

Carcinogenic DNA viruses such as high-risk human papillomaviruses (HPV) and Epstein-Barr-Virus (EBV) replicate during persistent infections as low-copy-number plasmids. EBV DNA replication is restricted by host cell replication licensing mechanisms. In contrast, copy number control of HPV genomes is not under cellular control but involves the viral sequence-specific DNA-binding E2 activator and E8-E2C repressor...

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Identifiers

PMID: 14585992
DOI: 10.1128/MCB.23.22.8352-8362.2003
PMCID: PMC262328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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