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Article

A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling

10 Oct 2019

Abstract excerpt

Fbxo7 is the substrate-recognition subunit of an SCF-type ubiquitin E3 ligase complex. It has physiologically important functions in regulating mitophagy, proteasome activity and the cell cycle in multiple cell types, like neurons, lymphocytes and erythrocytes. Here we show that in addition to the previously-known Parkinsonian and haematopoietic phenotypes, Fbxo7-deficient male mice are completely sterile. In...

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PMID: 31649556
DOI: 10.3389/fphys.2019.01278

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