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Article

In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene.

Toxicology letters - 15 Jan 2010

Piccoli P, Carrieri M, Padovano L, Di Mare M, Bartolucci G B, Fracasso M E, Lepera J S, Manno M

Abstract excerpt

Assessing CYP2E1 phenotype in vivo may be important to predict individual susceptibility to those chemicals, including benzene, which are metabolically activated by this isoenzyme. Chlorzoxazone (CHZ), a specific CYP2E1 substrate, is readily hydroxylated to 6-OH-chlorzoxazone (6-OH-CHZ) by liver CYP2E1 and the metabolic ratio 6-OH-CHZ/CHZ in serum (MR) is a specific and sensitive biomarker of CYP2E1 activity in...

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Source

Identifiers

PMID: 19900514
DOI: 10.1016/j.toxlet.2009.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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