Article
Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.
Cancer research - 15 Jul 1997
Rothman N, Smith M T, Hayes R B, Traver R D, Hoener B, Campleman S, Li G L, Dosemeci M, Linet M, Zhang L, Xi L, Wacholder S, Lu W, Meyer K B, Titenko-Holland N, Stewart J T, Yin S, Ross D
Abstract excerpt
Benzene is a ubiquitous occupational hematotoxin and leukemogen, but people vary in their response to this toxic agent. To evaluate the impact of interindividual variation in enzymes that activate (i.e., CYP2E1) and detoxify (i.e., NQO1) benzene and its metabolites, we carried out a case-control...
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