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Article

Mice with mutations in the HPA-system as models for symptoms of depression.

Biological psychiatry - 15 Jun 2006

Müller Marianne B, Holsboer Florian

Abstract excerpt

Genetically engineered mice hold promise to help us understand the effects of enhanced or reduced gene activity upon behavior and metabolism. Because many basic and clinical studies suggest that alterations of the hypothalamic pituitary adrenocortical (HPA) system are involved in the development and course of depression, mouse mutants with genetic modifications of genes regulating the HPA system were generated....

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PMID: 16581037
DOI: 10.1016/j.biopsych.2006.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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