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Article

Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.

Atherosclerosis - 1 Mar 2007

Zhang Yuan-Yuan, Gottardo Lucia, Mlynarski Wojciech, Frazier Winfred, Nolan David, Duffy Jill, Marescotti Maria Cristina, Gervino Ernest V, Johnstone Michael T, Mantzoros Christos S, Avogaro Angelo, Doria Alessandro

Abstract excerpt

OBJECTIVE: Cellular and animal studies suggest that leptin has proinflammatory and prothrombotic effects that could link increased adipose mass directly to atherogenesis. To investigate this hypothesis, we examined the effect of genetic variability at the leptin receptor (LEPR) locus on the plasma levels of fibrinogen and CRP--two markers of inflammation and susceptibility to atherosclerosis. METHODS AND RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16580675
DOI: 10.1016/j.atherosclerosis.2006.02.043

Genes

CRP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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