Article
Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.
Genetics - 1 Nov 2001
Heo M, Leibel R L, Boyer B B, Chung W K, Koulu M, Karvonen M K, Pesonen U, Rissanen A, Laakso M, Uusitupa M I, Chagnon Y, Bouchard C, Donohoue P A, Burns T L, Shuldiner A R, Silver K, Andersen R E, Pedersen O, Echwald S, Sørensen T I, Behn P, Permutt M A, Jacobs K B, Elston R C, Hoffman D J, Allison D B
Abstract excerpt
Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than conventional metaanalysis based on within-study estimates. However, conducting analyses with pooled genetic data, in particular, is a daunting task that raises important statistical issues. In the process of analyzing data pooled from nine studies on the human...
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