Article
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 May 2002
Heo M, Leibel R L, Fontaine K R, Boyer B B, Chung W K, Koulu M, Karvonen M K, Pesonen U, Rissanen A, Laakso M, Uusitupa M I J, Chagnon Y, Bouchard C, Donohoue P A, Burns T L, Shuldiner A R, Silver K, Andersen R E, Pedersen O, Echwald S, Sørensen T I A, Behn P, Permutt M A, Jacobs K B, Elston R C, Hoffman D J, Gropp E, Allison D B
Abstract excerpt
METHODS: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m(2)) and waist circumference (WC). A total of 3263 related and unrelated subjects from diverse ethnic backgrounds including African-American, Caucasian, Danish, Finnish, French Canadian and Nigerian were studied. We tested...
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