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Article

Leptin gene polymorphism is associated with hypertension independent of obesity.

The Journal of clinical endocrinology and metabolism - 1 Jun 2002

Shintani Maki, Ikegami Hiroshi, Fujisawa Tomomi, Kawaguchi Yoshihiko, Ohishi Mitsuru, Katsuya Tomohiro, Higaki Jitsuo, Shimamoto Kazuaki, Ogihara Toshio

Abstract excerpt

Leptin is an adipocyte-derived hormone that regulates food intake and energy expenditure. Recent functional studies have suggested a direct effect of leptin on blood pressure. In this study we examined the genetic association of the leptin gene polymorphism with obesity, insulin resistance, and hypertension. A highly polymorphic tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene was...

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Source

Identifiers

PMID: 12050272
DOI: 10.1210/jcem.87.6.8595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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