Article
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects.
Nutrients - 13 Nov 2019
Ortega-Azorín Carolina, Coltell Oscar, Asensio Eva M, Sorlí Jose V, González José I, Portolés Olga, Saiz Carmen, Estruch Ramon, Ramírez-Sabio Judith B, Pérez-Fidalgo Alejandro, Ordovas Jose M, Corella Dolores
Abstract excerpt
Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating polymorphisms in candidate genes have been inconsistent, and, in addition, very few genome-wide association studies (GWAS) have been undertaken. Our aim was to investigate the genes and gene...
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