Article
Interleukin-10 haplotypes in Celiac Disease in the Spanish population.
BMC medical genetics - 31 Mar 2006
Núñez Concepción, Alecsandru Diana, Varadé Jezabel, Polanco Isabel, Maluenda Carlos, Fernández-Arquero Miguel, de la Concha Emilio G, Urcelay Elena, Martínez Alfonso
Abstract excerpt
BACKGROUND: Celiac disease (CD) is a chronic disorder characterized by a pathological inflammatory response after exposure to gluten in genetically susceptible individuals. The HLA complex accounts for less than half of the genetic component of the disease, and additional genes must be implicated. Interleukin-10 (IL-10) is an important regulator of mucosal immunity, and several reports have described alterations...
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