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Article

TNFA Haplotype Genetic Testing Improves HLA in Estimating the Risk of Celiac Disease in Children.

PloS one - 1 Jan 2015

Rossi Elisa, Basso Daniela, Zambon Carlo-Federico, Navaglia Filippo, Greco Eliana, Pelloso Michela, Artuso Serena, Padoan Andrea, Pescarin Matilde, Aita Ada, Bozzato Dania, Moz Stefania, Cananzi Mara, Guariso Graziella, Plebani Mario

Abstract excerpt

BACKGROUND: TNF-α and IFN-γ play a role in the development of mucosal damage in celiac disease (CD). Polymorphisms of TNFA and IFNG genes, as well as of the TNFRSF1A gene, encoding the TNF-α receptor 1, might underlie different inter-individual disease susceptibility over a common HLA risk background. The aims of this study were to ascertain whether five SNPs in the TNFA promoter...

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Share to Celiac Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infant

Share to Interferon-gamma

Share to Promoter Regions, Genetic

Share to Receptors, Tumor Necrosis Factor, Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 25915602
DOI: 10.1371/journal.pone.0123244
PMCID: PMC4411089

Genes

IFNG
TNF

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