Article
Interleukin-18 gene promoter polymorphisms and celiac disease in Italian patients.
Molecular biology reports - 1 Feb 2015
Zupin Luisa, Catamo Eulalia, Polesello Vania, Crovella Sergio, Segat Ludovica
Abstract excerpt
Celiac disease (CD) is the most common food-sensitive enteropathy in genetically susceptible individuals. The major genetic risk factors known are specific human leukocyte antigen (HLA)-DQ haplotypes, but other genetic factors are supposed to be involved. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that has an important role in the immune defense and it has the potential to influence inflammatory...
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