Article
Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep.
The Journal of pathology - 1 May 2006
Jeffrey M, González L, Espenes A, Press C McL, Martin S, Chaplin M, Davis L, Landsverk T, MacAldowie C, Eaton S, McGovern G
Abstract excerpt
To determine the mechanisms of intestinal transport of infection, and early pathogenesis, of sheep scrapie, isolated gut-loops were inoculated to ensure that significant concentrations of scrapie agent would come into direct contact with the relevant ileal structures (epithelial, lymphoreticular, and nervous). Gut loops were inoculated with a scrapie brain pool homogenate or normal brain or sucrose solution....
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